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Introducing the Greenbrook T205-C 7 Day Fused Spur Timeswitch - the ultimate solution for those looking to control their electrical devices with precision and ease. This versatile timeswitch is designed to give you complete control over when your appliances turn on and off, helping you to save energy and money in the process. Barthelemy, N. R. et al. Tau protein quantification in human cerebrospinal fluid by targeted mass spectrometry at high sequence coverage provides insights into its primary structure heterogeneity. J. Proteome Res. 15, 667–676 (2016).
Quiroz, Y. T. et al. Cortical atrophy in presymptomatic Alzheimer’s disease presenilin 1 mutation carriers. J. Neurol. Neurosurg. Psychiatry 84, 556–561 (2013). This timeswitch is perfect for a variety of applications, including lights, heaters, fans, and other electrical devices. Its compact design means that it won't take up valuable space, and its high-quality construction ensures that it will last for years to come. Kimura, T., Sharma, G., Ishiguro, K. & Hisanaga, S. Phospho-tau bar code: analysis of phosphoisotypes of tau and its application to tauopathy. Front. Neurosci. 12, 44 (2018). Benzinger, T. L. et al. Regional variability of imaging biomarkers in autosomal dominant Alzheimer’s disease. Proc. Natl Acad. Sci. USA 110, E4502–E4509 (2013).
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Morris, J. C. The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology 43, 2412–2414 (1993). Medina, M. & Avila, J. Further understanding of tau phosphorylation: implications for therapy. Expert Rev. Neurother. 15, 115–122 (2015). Arriagada, P. V., Growdon, J. H., Hedley-Whyte, E. T. & Hyman, B. T. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer’s disease. Neurology 42, 631–639 (1992). Conforms to: BS 1363-4:1995+A4:2012, BS EN 60730-1:2011, BS EN 60730-2-7:2010, BS 4662:2006+A1:2009
He, Z. et al. Amyloid-β plaques enhance Alzheimer’s brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation. Nat. Med. 24, 29–38 (2018). Yanamandra, K. et al. Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy. Sci. Transl. Med. 9, eaal2029 (2017). Yamada, K. et al. In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice. J. Neurosci. 31, 13110–13117 (2011). Sato, C. et al. Tau kinetics in neurons and the human central nervous system. Neuron 98, 861–864 (2018). Buerger, K. et al. CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer’s disease. Brain 129, 3035–3041 (2006).Schelle, J. et al. Prevention of tau increase in cerebrospinal fluid of APP transgenic mice suggests downstream effect of BACE1 inhibition. Alzheimers Dement. 13, 701–709 (2017). Goedert, M., Spillantini, M. G., Jakes, R., Rutherford, D. & Crowther, R. A. Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer’s disease. Neuron 3, 519–526 (1989).