Apigenin 100mg x 90 Capsules - Third Party Tested Over 98% - Natural Apigenin Supplement Vitality Pro

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Taken together, the evidence is insufficient to conclude that apigenin helps in cancer prevention. The human studies had mainly negative results, and those showing anticancer activity were mostly done in cells. Multiple studies have been performed to measure the distribution and excretion of apigenin in vivo. Following an IV bolus injection of apigenin at 20 mg/kg, the mean value of systemic clearance was 6.12 ± 0.79 L/h/kg [ 61]. In the previously mentioned study with rats, after a single oral administration of radiolabeled apigenin, the elimination half-time was high with a value of 91.8 hours [ 59]. The distribution volume was 259 mL, and the plasmatic clearance was 1.95 mL/h [ 59]. After 10 days, 1.2% of the radioactivity was recovered in the blood, 0.4% in the kidneys, 9.4% in the intestine, 1.2% in the liver, and 24.8% in the rest of the body [ 59]. About half the apigenin consumed went into urine and feces [ 59]. In another study, mice were fed a diet containing apigenin for 5, 6, or 7 days. It was found that with a dose of 1.1 mmol/kg apigenin, plasma levels of apigenin reached steady state after 5 days and the steady-state concentrations of apigenin in plasma, liver, and the small intestinal mucosa were 0.09 ± 0.08 nmol/mL, 1.5 ± 1.0 nmol/g, and 86 ± 47 nmol/g, respectively [ 62]. This is in the similar range to the other study. Apigenin distributes well into the tissues [ 57]. 5.3. Metabolism As can be concluded from the Ames tests and hemolytic tests, apigenin is not mutagenic nor hemolytic. Taking apigenin glucosides through a daily diet can hardly reach the therapeutic doses used in clinical trial [ 4] and has not been reported to be harmful. However, as consumers intentionally increase apigenin intake from dietary supplements or pharmaceutical sources, safety concerns may arise with a higher level of apigenin exposure. 5. Pharmacokinetics: Absorption, Distribution, Metabolism, and Excretion Panés J, Gerritsen ME, Anderson DC, Miyasaka M, Granger DN Apigenin inhibits tumor necrosis factor-induced intercellular adhesion molecule-1 upregulation in vivo. Microcirculation. (1996-Sep)

Rats experiencing a severe reaction to infection (sepsis) had reduced inflammatory responses when treated with apigenin [ 12]. Become a savvy supplement shopper. Learn how to spot the hidden signs of low-quality products and save money by avoiding ineffective supplements. Cancer is a disease where cells grow uncontrollably and spread to other parts of the body. Chemotherapy is promoted as the best way to manage and kill cancer cells, despite its undesirable side effects. Therefore, scientists are testing and trialling compounds, like Apigenin, to treat various forms of this condition. Apart from mutagenesis, hemolytic activity is another measurement of safety. Hemolytic tests showed that the percent hemolysis of apigenin was below the permissible limit of 5% after 30 min treatment. Being hemocompatible indicates that apigenin is safe for intravenous application, and suggests that apigenin is non-toxic in mammalian systems [ 55]. Apigenin was able to significantly attenuate the hemolytic activity of the purified Pneumolysin, the pore-forming toxin secreted by S. pneumoniae, in a concentration-dependent manner [ 56]. It’s easy to get this powerful nutrient in foods. In fact, it’s present in fruits, vegetables, herbs and beverages that many of us already consume regularly.We are dedicated to providing the most scientifically valid, unbiased, and comprehensive information on any given topic. Apigenin supports cardiovascular health by reducing blood pressure and inflammation. Animal models show that it has cardioprotective effects in rats with heart damage. Rahmati M, Ghannadian SM, Kasiri N, Ahmadi L, Motedayyen H, Shaygannejad V, Pourazar A, Alsahebfosoul F, Ganjalikhani Hakemi M, Eskandari N Modulation of Th17 Proliferation and IL-17A Gene Expression by Acetylated Form of Apigenin in Patients with Multiple Sclerosis. Immunol Invest. (2021-Feb) Research on apigenin first began in the 1960s, and it was proposed to be chemo-preventative in the 1980s [ 9, 13, 51]. Recently, apigenin has received much attention because it has low intrinsic toxicity [ 4, 44] and it exerts differential effects on normal versus cancer cell growth, survival, or apoptosis in several different types of cells [ 9, 13, 52].

Ohno S, Shinoda S, Toyoshima S, Nakazawa H, Makino T, Nakajin S Effects of flavonoid phytochemicals on cortisol production and on activities of steroidogenic enzymes in human adrenocortical H295R cells. J Steroid Biochem Mol Biol. (2002-Mar) Apigenin is considered safe when consumed in normal amounts through a diet rich in fruits, vegetables and herbs. If you experience stomach discomfort after consuming chamomile extract, which is sometimes taken for its high levels of apigenin, then discontinue use immediately. Quercetin, apigenin, epigallocatechin gallate (EGCG), resveratrol, curcumin, and tamoxifen were investigated as inhibitory agents of the growth and metastatic potential of B16-BL6 melanoma cells in vivo in a syngeneic mouse model [ 87]. They found that quercetin at 25 and 50 mg/kg as well as apigenin at 25 and 50 mg/kg, and epigallocatechin gallate, resveratrol, and tamoxifen at 50 mg/kg, significantly delayed tumor growth. They found that at the dose of 50 mg/kg, EGCG, apigenin, and quercetin were the most effective. In addition, cisplatin, at 2 mg/kg, significantly inhibited melanoma growth, and apigenin, at 25 mg/kg, potentiated the effect without mortality or body weight loss. Furthermore, the authors found that quercetin and apigenin, at 25 mg/kg as well as 50 mg/kg, significantly decreased the number of lung metastatic colonies, while other tested polyphenols were not active even at higher concentrations. Thus, it was concluded that apigenin not only inhibits the growth of melanoma cells, but also shows anti-invasive potential. Direct evidence supporting Apigenin's ability to cause weight loss is weak and limited, however, it has been shown to increase a powerful coenzyme called NAD+. NAD+ is involved in numerous metabolic processes but turning food into energy, and regulating metabolism appears to be its most critical. As we age, NAD+ levels decline, and evidence is beginning to suggest that if levels are maintained its fights against the ageing process and obesity. Apigenin was able to increase NAD+ in obese mice and consequently benefited fat and glucose metabolism ( 6). More studies are required as this research is preliminary. Sleep and Anxiety SupportThis explains why chamomile tea can have beneficial effects on anxiety and help aid relaxation and sleep. Viola H, Wasowski C, Levi de Stein M, Wolfman C, Silveira R, Dajas F, Medina JH, Paladini AC Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects. Planta Med. (1995-Jun) The bioflavonoid has gained attention after researchers reported on its low toxicity and beneficial bioactivities.