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Funding The study is supported by an unrestricted grant from Goodlife Pharma BV. This company has developed and marketed Impryl. The grant is unrestricted in means that the funder did not have any role in the design of the study, collection, analysis and/or interpretation of data. The investigators have full access to the data and have the right to publish these data separate and apart from any sponsor.
Infertility can be a lonely, all-consuming place to be. It can affect every aspect of your life. You may have been trying to get pregnant for a while, you may need help trying to conceive, you may be going through fertility treatment and want to optimise your fertility or you may have only just decided that you want to get pregnant. Whatever the case, we want to reassure you that you aren’t alone — we provide information and products to support your fertility. Inofolic ® Alpha and Impryl ® are fertility supplements that focus on helping both the sperm and the egg to be of optimal quality to help you enjoy a healthy pregnancy. Homocysteine is a naturally occurring, non-proteinogenic amino acid that accumulates when One Carbon Metabolism (OCM) is suboptimal. Elevated levels of homocysteine are a risk factor for multiple human reproductive health issues, including both male and female infertility, preeclampsia, miscarriage, and birth defects like spina bifida. Homocysteine is recycled to methionine through methylation by the methionine and betaine pathway of OCM, or converted to cystathione by the transsulfuration pathway of OCM. What is glutathione? The remaining SUSARs are recorded in an overview list (line listing) that will be submitted once every half year to the METC. This line listing provides an overview of all SUSARs from the study medicine, accompanied by a brief report highlighting the main points of concern. The expedited reporting of SUSARs through the web portal Eudravigilance or ToetsingOnline is sufficient as notification to the competent authority. Yes, Impryl can be used by individuals who consciously choose to avoid products of animal origin. In addition, none of the ingredients in Impryl are produced using genetically modified organisms (GMO). Does IMPRYL® contain any artificial colors or flavors?
Driving biology to support fertility
Impryl’s unique balance of micronutrients prevents DNA fragmentation without causing DNA de-condensation. Vitamin B2, B3 and B6 are all necessary cofactors for the critical enzymes in One Carbon Metabolism (OCM). What is the importance of zinc? OCM is important because it functionally connects the dietary intake of micronutrients with critical biological processes, including homocysteine recycling, DNA/RNA synthesis, cellular energy production, natural antioxidant activity and gene expression. Learn about how Impryl works. Disruption of OCM by diet, environmental exposure or genetic variations is associated with multiple human reproductive health problems, including reduced sperm health and egg quality, infertility and miscarriage, as well as birth defects, including spina bifida. What is a methyl group? Fertility Family is part of Health Medica, a UK healthcare company. Our range of high quality products is recommended by fertility specialists across the UK. Read more about us. I wanted to post this because I felt devastated after the first analysis. Every single one of my husband’s parameters, including count, has improved drastically in % terms.
Impryl contains riboflavin (Vitamin B2), niacin (Vitamin B3), pyridoxine (Vitamin B6), 5-methyltetrahydrofolate (activated Vitamin B9), methylcobalamin (activated Vitamin B12), zinc, betaine and L-cystine. These ingredients are either essential (must be consumed in the diet) or semi-essential (can be made in the body, but typically not in sufficient quantities) and several are in their activated forms (don’t require processing by the body). DNA fragmentation is the ‘snipping up’ of DNA in the sperm head, which can contribute towards difficulties in conceiving and/or miscarriage. DNA fragmentation is often treated with strong anti-oxidants such as Vitamin C, Vitamin E, Selenium, CoQ10, Vitamin A and Carotenoids. However, we now know that although they might prevent DNA fragmentation, these strong anti-oxidants can then cause DNA de-condensation, which is the unravelling of the DNA in the sperm head, meaning that conception is not possible at all. Standard sperm tests focus on quantity, motility and morphology but do not test for DNA fragmentation. Contributors Study concept and design were conducted by authors RS and KF. Advanced statistical input was given by author JIH. Critical revision of concept and design and intellectual input in the study protocol were done by authors RS, KF, KD'H, JIH and DB. Study supervision and coordination were conducted by authors RS and KF. Glutathione (GSH) is the main antioxidant in the human body. It diffuses everywhere and continuously re-charges with antioxidant power all the other physiologic antioxidants. Important, GSH is not a dietary substance and is not provided by the diet neither can be assumed as a supplement. Glutathione is synthesized by the transsulfuration pathway of One Carbon Metabolism (OCM) using homocysteine/cysteine as the main substrate.I had been diagnosed with asthenozoospermia (not enough motility) and my volume was consistently lower than average. Although Impryl cannot increase your ovarian reserve, it can maximise the quality of eggs available. Impryl is manufactured in the Italy using domestic and imported ingredients in a facility that is certified to current good manufacturing practice (cGMP) standards. Following manufacturing, each lot of Impryl is laboratory tested and released for sale only after demonstrating compliance with product-specific acceptance criteria. Is IMPRYL® Gluten-Free? At least two semen analyses will be performed at two time points in this study: the first semen analysis will be performed during diagnostic workup (standard care and analysis according to WHO criteria 37) and the second one after approximately 3 months of using study medication for participants having the IUI or IVF/ICSI treatment. We decided not to perform a second semen analysis in the EM group due to the fact that they present with normal semen parameters at intake, and we want to avoid the burden of an extra visit.
Like I said nothing had changed in our diet and our physical relationship was still the same from before we started ttc… which is a long time! There are many reasons why so many of us have difficulties with fertility. With 1 in 6 couples needing medical help to get pregnant and the causes of infertility being almost equally spread between men and women, it’s important to understand what factors can impact your fertility. Aside from any obvious medical health problems, lifestyle choices, environmental factors, diet and age can affect the chances of getting pregnant. For example, fertility in women starts to drop after reaching 35. This is because the age of the egg is a critical factor in achieving pregnancy. Women with PCOS often have difficulty ovulating and therefore have problems conceiving. Epidemiological studies have shown environmental factors have played a part in sperm counts dropping over the last 50 years and this trend continues. Even men with a ‘normal’ sperm count can have other problems such as DNA fragmentation, which can cause infertility and increase the incidence of miscarriage. Optimise your fertility
Manufactured to the highest standard
Impryl ingredients were carefully selected because each plays an important role in a process in your body called One Carbon Metabolism (OCM). OCM uses the micronutrients provided by Impryl to power five biological processes – homocysteine recycling, DNA/RNA synthesis, cellular energy production, natural antioxidant activity and gene expression – each important for sperm health and egg quality, fertilization, and the growth and development of the baby. What is One Carbon Metabolism (OCM)?
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