Pro-Ven Probiotics Adult Digestive Supplement Vegan Acidophilus & Bifidus 25 Billion CFU Capsules Multi-Strain High Strength Friendly Bacteria 30 Capsules - UK Made

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This microbiome is made up of many different species of bacteria, some of which are considered friendly and others termed pathogenic. The bacteria line the gut wall and help to stop toxins and harmful substances passing through the gut into the body – so ideally, we need a lot more good than bad. The ideal ratio has been estimated at 85% good to 15% bad bacteria and if this balance is affected it may lead to digestive symptoms such as bloating or irritable bowel syndrome (IBS). Research shows that people who are overweight are more likely to have dysbiosis (an imbalance in gut bacteria) and lower bacterial diversity than people who are not. This may increase hunger and increase energy storage in fat tissues, which contributes to weight gain. Bosch M, Fuentes MC, Audivert S, Bonachera MA, Peiro S, Cune J. Lactobacillus plantarum CECT 7527, 7528 and 7529: probiotic candidates to reduce cholesterol levels. J Sci Food Agric 2014;94:803-9. [ PubMed abstract]

Kumar R, Grover S, Batish VK. Bile salt hydrolase (Bsh) activity screening of lactobacilli: in vitro selection of indigenous Lactobacillus strains with potential bile salt hydrolysing and cholesterol-lowering ability. Probiotics Antimicrob Proteins 2012;4:162-72. [ PubMed abstract] Food and Drug Administration. Policy regarding quantitative labeling of dietary supplements containing live microbials: Guidance for industry . 2018. Notably, Lactobacillus acidophilus was present in all of the multistrain supplement studies that reported significant improvements. The company is owned and managed by Dr Nigel Plummer, a world-renowned expert in the field of probiotics.Healthy bacteria are required to support both the digestive tract and the urogenital tract in women. For example, most urinary tract infections (UTIs), often referred to as cystitis, are caused by a species of bacteria called Escherichia coli ( E. coli), which generally live happily alongside the good bacteria in the gut and urogenital tract, but can sometimes grow and cause infection. Yakusara Z, et al. (2019). Effect of repeated consumption of partially hydrolyzed guar gum on fecal characteristics and gut microbiota: A randomized, double-blind, placebo-controlled, and parallel-group clinical trial.

Mourey F, et al. (2020). A multicenter, randomized, double-blind, placebo-controlled trial of Saccharomyces boulardii in infants and children with acute diarrhea. Whether different strains of probiotic bacteria have beneficial effects on IBS probably depends on the IBS symptom being evaluated [ 48]. In a meta-analysis of 10 RCTs with a total of 877 adults treated with probiotics or placebo for 4 weeks to 6 months, pain scores improved significantly with administration of probiotics containing Bifidobacterium breve, Bifidobacterium longum, or Lactobacillus acidophilus species compared with placebo treatment [ 49]. In contrast, Streptococcus salivarius ssp. thermophilus, Bifidobacterium animalis, Bifidobacterium infantis, Lactobacillus casei, Lactobacillus plantarum, Lactobacillus bulgaricus, and Saccharomyces boulardii had no significant effect. The abdominal distension scores improved with use of probiotics containing Bifidobacterium breve, Bifidobacterium infantis, Lactobacillus casei, or Lactobacillus plantarum species. Flatulence declined with use of all tested probiotics, but the studies showed no positive effect of probiotics on quality of life. Garden of Life Dr. Formulated Probiotics Once Daily, 30 Billion CFUs provides 30 billion CFUs of 14 probiotic strains, including Lactobacillus gasseri and L. rhamnosus, which could help support weight loss. Culturelle is a well-known brand of probiotics and is one of the best overall probiotic supplements thanks to its formulation and high CFU count. Plus, it doesn’t need to be refrigerated. Results of clinical trials that assessed the impact of probiotics on obesity-related endpoints have been inconsistent. One 12-week clinical trial, for example, randomized 210 healthy adults age 35 to 60 years who had large amounts of visceral fat to consume 200 g/day fermented milk containing 10 7, 10 6, or 0 (control) CFU of Lactobacillus gasseri SBT2055 (LG2055) per gram of milk [ 59]. Participants who received 10 7 or 10 6 CFU/g milk of Lactobacillus gasseri experienced significant reductions in visceral fat area (mean reductions of 8.5% and 8.2%, respectively), body mass index, waist and hip circumference, and body fat mass compared with the control group. In another randomized clinical trial, daily supplementation with 3.24 x 10 8 CFU Lactobacillus rhamnosus CGMCC1.3724 for 24 weeks combined with an energy-restricted diet for the first 12 weeks (500 kcal/day less than estimated calorie needs) did not significantly affect weight loss compared with placebo in 125 adults age 18 to 55 years with obesity [ 60]. However, the Lactobacillus supplementation did significantly reduce body weight after 12 weeks (loss of 1.8 kg) and 24 weeks (loss of 2.6 kg) compared with placebo in the 77 female participants.Venema K, et al. (2019). Probiotic survival during a multi‐layered tablet development as tested in a dynamic, computer‐controlled in vitro model of the stomach and small intestine (TIM‐1). Miller L, et al. (2019). Short-term probiotic supplementation enhances cellular immune function in healthy elderly: systematic review and meta-analysis of controlled studies. American Gastroenterological Association. Consideration for use of probiotics in gastrointestinal diseases: clinical decision support tool. Gastroenterology 2020; 159: 706. [ PubMed abstract] Williams EA, Stimpson J, Wang D, Plummer S, Garaiova I, Barker ME, et al. Clinical trial: a multistrain probiotic preparation significantly reduces symptoms of irritable bowel syndrome in a double-blind placebo-controlled study. Aliment Pharmacol Ther 2009;29:97-103. [ PubMed abstract] Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults. Gut 2019; 68(Suppl 3): s1-s106.

Bafeta A, Koh M, Riveros C, Ravaud P. Harms reporting in randomized controlled trials of interventions aimed at modifying microbiota: a systematic review. Ann Intern Med 2018;169:240-7. [ PubMed abstract] The microbiome is made up of many different species of bacteria, some of which are considered friendly and others termed pathogenic. The bacteria line the gut wall and help to stop toxins and harmful substances passing through the gut into the body – so ideally, we need a lot more good than bad. The ideal ratio has been estimated at 85% good to 15% bad bacteria and if this balance is affected it may lead to digestive symptoms such as bloating or irritable bowel syndrome (IBS).Wilkins T Sequoia J. Probiotics for gastrointestinal conditions: a summary of the evidence. Am Fam Physician 2017; 96: 170-8. [ PubMed abstract] Probiotics are thought to help restore the natural balance of bacteria in your gut (including your stomach and intestines) when it's been disrupted by an illness or treatment.

Crovesy L, Ostrowski M, Ferreira D, Rosado EL, Soares-Mota M. Effect of Lactobacillus on body weight and body fat in overweight subjects: a systematic review of randomized controlled clinical trials. Int J Obes (Lond) 2017;41:1607-14. [ PubMed abstract] Blaabjerg S, Artzi DM, Aabenhus R. Probiotics for the prevention of antibiotic-associated diarrhea in outpatients-a systematic review and meta-analysis. Antibiotics (Basel) 2017;6. [ PubMed abstract] Guarino A, Ashkenazi S, Gendrel D, Lo Vecchio A, Shamir R, Szajewska H, et al. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition/European Society for Pediatric Infectious Diseases evidence-based guidelines for the management of acute gastroenteritis in children in Europe: update 2014. J Pediatr Gastroenterol Nutr 2014;59:132-52. [ PubMed abstract]

Friendly bacteria and vitamins C and D developed specifically for children

Caffarelli C, Cardinale F, Povesi-Dascola C, Dodi I, Mastrorilli V, Ricci G. Use of probiotics in pediatric infectious diseases. Expert Rev Anti Infect Ther 2015;13:1517-35. [ PubMed abstract] Probiotic strains: Probiotics are not one-size-fits-all remedies, and certain probiotic strains are much more effective for certain medical conditions and symptoms than others. Look for supplements with specific strains based on your needs. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy. ProVen Women’s Lactobacillus & Bifidus with Cranberry contains three Lactobacillus strains – two Lactobacillus acidophilus strains and Lactobacillus gasseri, which is a key part of the vaginal flora.