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B Braun D5613 Wound Irrigation Solution, 350ml

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Newton H, Edwards J, Mitchell L, Percival SL. Role of slough and biofilm in delaying healing in chronic wounds: The management of biofilms with maintenance desloughing and antimicrobial therapy is fast becoming the accepted treatment strategy for chronic wounds. British journal of nursing 2017; 20(S20a): S4-S11. Surgiphor Wound Irrigation System FDA. [last access: 1May2021]. available at: https://www.accessdata.fda.gov/cdrh_docs/pdf20/K202071.pdf . Produces chloride ions, a potent oxidizer that inhibits protein synthesis and essential lipids in the bacterial cell membrane, resulting in its antimicrobial effect. Total Knee Arthroplasty Revision Surgery in Known Cases of Prosthetic Joint Infection. [last access: 10May2021]; 2019 available at: https://www.zimmerbiomet.com/content/dam/zimmer-biomet/medical-professionals/surgical-and-cement/bactisure-wound-lavage/2656.1%20US-en%20Bactisure%20White%20Paper.pdf . [ Google Scholar] Atkin L, Stephenson J, Cooper DM. Wound bed preparation: a case series using polyhexanide and betaine solution and gel—a UK perspective. Journal of Wound Care 2020; 29(7): 380-6.

Marx RG, Wilson SM, Swiontkowski MF. Updating the Assignment of Levels of Evidence. Journal Bone Joint Surg. 2015; 97:1–2. doi: 10.2106/JBJS.N.01112. [ PubMed] [ CrossRef] [ Google Scholar]Blom A, Cho J, Fleischman A, Goswami K, Ketonis C, Kunutsor SK, Makar G, Meeker DG, Morgan-Jones R, Ortega-Peña S, Parvizi J, Smeltzer M, Stambough JB, Urish K, Ziliotto G. General Assembly, Prevention, Antiseptic Irrigation Solution: Proceedings of Lu M, Hansen EN. Hydrogen Peroxide Wound Irrigation in Orthopaedic Surgery. J Bone Joint Infect. 2017; 2:3–9. doi: 10.7150/jbji.16690. [ PMC free article] [ PubMed] [ CrossRef] [ Google Scholar] Campbell ST, Goodnough LH, Bennett CG, Giori NJ. Antiseptics Commonly Used in Total Joint Arthroplasty Interact and May Form Toxic Products. J Arthroplasty. 2018; 33:844–846. [ PubMed] [ Google Scholar]

Byren I, Bejon P, Atkins BL, Angus B, Masters S, McLardy-Smith P, Gundle R, Berendt A. One hundred and twelve infected arthroplasties treated with “DAIR” (debridement, antibiotics and implant retention): antibiotic duration and outcome. J Antimicrob Chemoth. 2009; 63:1264–1271. [ PMC free article] [ PubMed] [ Google Scholar] TKA: 96.8% (487/503) at 3 months 93.4% (298/319) at 12 months THA: 96.3% (367/381) at 3 months 94.8% (219/231) at 12 months Tsang STJ, Gwynne PJ, Gallagher MP, Simpson AHRW. The biofilm eradication activity of acetic acid in the management of periprosthetic joint infection. Bone Joint Res. 2018; 7:517–523. doi: 10.1302/2046-3758.78.BJR-2018-0045.R1. a. [ PMC free article] [ PubMed] [ CrossRef] [ Google Scholar]Van Meurs SJ, Gawlitta D, Heemstra KA, Poolman RW, Vogely HC, Kruyt MC. Selection of an optimal antiseptic solution for intraoperative irrigation: An in vitro study. J Bone Joint Surg Am. 2014; 96:285–291. [ PubMed] [ Google Scholar] In Vitro Evaluation of Polihexanide, Octenidine and NaClO/HClO-BasedAntiseptics against Biofilm Formed by Wound Pathogens Robson M. Treating Chronic Wounds With Hypochlorous Acid Disrupts Biofilm. Today's Wound Clinic. 2014; 8 [ Google Scholar] Ernest EP, Machi AS, Karolcik BA, LaSala PR, Dietz MJ. Topical adjuvants incompletely remove adherent Staphylococcus aureus from implant materials. J Orthop Res. 2018; 36:1599–1604. [ PMC free article] [ PubMed] [ Google Scholar] Atkin et al, (2020) Wound bed preparation: a case series using polyhexanide and betaine solution and gel—a UK perspective

Surgical debridement → modular component explantation → 3L PI b irrigation → PI b scrub brush mechanical scrub → 3L SH b irrigation → 3L Bacitracin b irrigation → 3L NS irrigation → re-drape → component implantation Cichos KH, Andrews RM, Wolschendorf F, Narmore W, Mabry SE, Ghanem ES. Efficacy of Intraoperative Antiseptic Techniques in the Prevention of Periprosthetic Joint Infection:Barros LH, Barbosa TA, Esteves J, Abreu M, Soares D, Sousa R. Early Debridement, antibiotics and implant retention (DAIR) in patients with suspected acute infection after hip or knee arthroplasty – safe, effective and without negative functional impact. J Bone Joint Infect. 2019; 4:300–305. doi: 10.7150/jbji.39168. [ PMC free article] [ PubMed] [ CrossRef] [ Google Scholar] Royo A, Bertrand ML, Ramos L, Fernandez-Gordillo F, Guerado E. Is there still a place for continuous closed irrigation in the management of periprosthetic total knee infection? Open Orthop J. 2013; 7:205–210. [ PMC free article] [ PubMed] [ Google Scholar] Goswami K, Austin MS. Intraoperative povidone-iodine irrigation for infection prevention. Arthroplasty Today. 2019; 5:306–308. a. [ PMC free article] [ PubMed] [ Google Scholar]

Clinician perspective on time and resource related to dressing changes. Available at https://www.wounds-uk.com/journals/issue/506/article-details/clinician-perspectives-on-time-and-resources-related-to-dressing-changes [accessed Jan 2021] Hunter C, Duncan S. Clinical Effectiveness of a Biofilm Disrupting Surgical Lavage in Reducing Bacterial Contamination in Murphy C, Atkin L, Swanson T, et al. Defying hard-to-heal wounds with an early antibiofilm intervention strategy: wound hygiene. Journal of Wound Care 2020; 29(Sup3b): S1-S26. Sloan M, Premkumar A, Sheth NP. Projected volume of primary total joint arthroplasty in the u.s., 2014 to 2030. J Bone Joint Surg Am. 2018; 100:1455–1460. [ PubMed] [ Google Scholar]Rabenberg VS, Ingersoll CD, Sandrey MA, Johnson MT. The bactericidal and cytotoxic effects of antimicrobial wound cleansers. J Athl Training. 2002; 37:51–54. [ PMC free article] [ PubMed] [ Google Scholar] saline (Goswami and Austin, 2019b). Recently in October2020, the Food and Drug Administration (FDA) approved the first sterile Alongside wound cleansing, debridement is often the first step in any protocol of wound care. The aim of debridement is to obtain a clean, healthy wound bed to allow rapid and effective healing. By removing devitalised tissue, excess exudate, senescent and abnormal cells, and microbial burden, healthy tissue is unimpeded, and granulation tissue encouraged to form in the wound bed (Halim et al, 2012). These factors allow wounds to progress to and through the final phase of wound healing and towards complete closure. 2 Ruder JA, Springer BD. Treatment of Periprosthetic Joint Infection Using Antimicrobials: Dilute Povidone–Iodine Lavage. J Bone Joint Infect. 2017; 2:10–14. doi: 10.7150/jbji.16448. [ PMC free article] [ PubMed] [ CrossRef] [ Google Scholar]

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