Healthspan Vein Vine 360mg (90 Tablets) | for Tired & Heavy Legs | Maintains Healthy Leg-Vein Functions | Red Vine Leaf Extract | Added Vitamins B1 & C | Vegan

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Red grapes are well-known for their beneficial antioxidants, and red vine leaf extracts are derived from the leaves of the same grapevine, Vitis vinifera. Red vine leaves are harvested when they achieve a rich red colour and have the highest content of antioxidant polyphenols. Their extracts are used medicinally for their circulatory effects, especially within leg veins. They reduce inflammation, stabilise the endothelial lining of capillaries and veins, and promote their repair to reduce swelling of the ankles. Red vine leaf benefits

In a study involving 30 people with acute deep vein thrombosis, all received usual medical treatment with anticoagulants, and half were also given red grape leaf extracts. Other studies found similar reductions in calf swelling, sensations of heaviness and pain from taking red vine leaf extracts. Red vine leaf and venous thrombosisRed Vine Leaf Extract, Vitamin C (as Ascorbic Acid), Capsule Shell (Hydroxypropyl Cellulose), Grapeseed Extract, Bulking Agent (Microcrystalline Cellulose), Anti-Caking Agents (Magnesium Stearate, Silicon Dioxide). Red vine leaf extract (RVLE) is a herbal medicine containing several flavonoids, with quercetin-3-O-beta-glucuronide and isoquercitrin (quercetin-3-O-beta-glycoside) as the main components.

To assess the efficacy and safety of once-daily doses of 360 and 720 mg RVLE (pharmaceutical extract code AS 195; Antistax Venenkapseln) compared to placebo in patients with stage I and incipient stage II chronic venous insufficiency (CVI). The researchers concluded that adding angioprotectors ( red vine leaf extract) to standard medical treatment helps to correct endothelial dysfunction (the ability of veins to recover and dilate) and may improve the immediate results for patients with acute venous thrombosis. Red vine leaf dose Chronic venous insufficiency (CVI) is common in adults. Some complications include skin changes, edema, heavy legs, muscle cramps, pain, and varicose veins. In traditional medicine, red vine leaf extract (AS 195) has been used to cure the symptoms of CVI. This systematic review was aimed to assess the effects of AS 195 in patients with CVI. Symptoms of chronic venous insufficiency include feelings of heaviness, aching legs, swelling of the ankles or calves, sensations of tension in the legs and pain. The overlying skin may become dry and discoloured and acquires a characteristic mottled pigmentation.

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Patients were randomly assigned to a double-blind treatment with placebo, 360 mg AS 195 or 720 mg AS 195 once daily for 12 weeks, preceded and followed by a single-blind 2-week placebo treatment for baseline run-in and end-of-trial washout, respectively. Study criteria were evaluated at baseline, after 6 and 12 weeks of treatment and 2 weeks after discontinuation of treatment.

Beebe-Dimmer, J. L., Pfeifer, J. R., Engle, J. S., & Schottenfeld, D. (2005). The epidemiology of chronic venous insufficiency and varicose veins. Annals of Epidemiology, 15(3), 175-184.In Germany, as many as 7 % of the general population take red vine leaf extracts (Antistax), usually on the advice of their doctor, to reduce swelling and other leg symptoms associated with chronic venous insufficiency.