SiderAL Forte 30caps

Product Information

Sukrosomiaalinen (Sucrosomial®) tekniikka suojaa rautaa ruoansulatuskanavassa, mikä vähentää raudalle tyypillisiä haittavaikutuksia, kuten suolisto-ongelmia, suun värjäytymistä ja makuhaittoja.

Hallberg L, Hulthén L (2000) Prediction of dietary iron absorption: an algorithm for calculating absorption and bioavailability of dietary iron. Am J Clin Nutr 71(5):1147–1160 Kassebaum NJ, Jasrasaria R, Naghavi M, Wulf SK, Johns N, Lozano R, Regan M, Weatherall D, Chou DP, Eisele TP, Flaxman SR, Pullan RL, Brooker SJ, Murray CJL (2014) A systematic analysis of global anemia burden from 1990 to 2010. Blood 123:615–624Munoz M, Acheson AG, Auerbach M et al (2017) International consensus statement on the peri-operative management of anaemia and iron deficiency. Anaesthesia 72:233–247 The highest total monthly median expenditures, accounting for 300 Euros, were reported in patients treated with SFGC, compared to patients supplemented with SI ( p< 0.001), accounting for 120 Euros. Although the unitary cost of a Sideral® pill box seems to be higher than that of a vial of Ferlixit® (EUR 20 per Sideral® box vs EUR 0.95/vial for i.v. iron), the highest direct (EUR 35 for doctor visit, EUR 35 for daily hospital admission, EUR 10 for outpatient hospital visit) and indirect (EUR 120 for a working day loss) costs were seen in the SFGC group, with a significant statistical difference ( p = 0.013). Napolitano M, Dolce A, Celenza G et al (2014) Iron-dependent erythropoiesis in women with excessive menstrual blood losses and women with normal menses. Ann Hematol 93:557–563. https://doi.org/10.1007/s00277-013-1901-3 Kalgaonkar S, Lonnerdal B (2009) Receptor-mediated uptake of ferritin- bound iron by human intestinal Caco-2 cells. J Nutr Biochem 20:304–311

Sideral r.m.®, Sucrosomial® željezni pirofosfat, smanjuje nuspojave koje su obično povezane s drugim vrstama željeza. Željezo je mikroelement u srži mnogih metaboličkih procesa, obavljajući ključne funkcije kao što su donošenje kisika u tkiva, prijenos elektrona tijekom disanja i pomaganje aktivnosti niza enzimskih sustava. Dnevna potreba za željezom varira u odnosu na različita fiziološka stanja ( menstruacija, krvarenje, trudnoća). Dakle, evidentna je važnost odgovarajućeg dodatka željeza za održavanje dobrog zdravstvenog stanja. Inclusion criteria were age > 18 years, no other established causes of anemia, hemoglobin < 10 g/dl, ferritin < 30 ng/ml, total iron binding capacity saturation < 20%, iron sulfate intolerance, failure to increase 1 g of hemoglobin (Hb) after 1-month treatment with iron sulfate at a dosage of 660 mg (2 tabs)/day, failure of normalization of the Hb level after 3 months of 660 mg of iron sulfate (2 tabs), at least one positive sample of fecal occult blood test out of three with esophageal gastro-duodenoscopy and pan colonoscopy negative for neoplasia, non-neoplastic hypermenorrhea, and/or menometrorrhagia, gastric bleeding (ulcer, gastritis, angiodysplasia), small intestine bleeding (angiodysplasia, ulcer), and colorectal bleeding (diverticulitis, angiodysplasia, hemorrhoids).

Features

SiderAL® FORTE on sukrosomiaalista (Sucrosomial®) rautaa ja C-vitamiinia sisältävä ravintolisä. Valitse SiderAL® FORTE kapselit, kun raudan saanti ruokavaliosta on vähäistä tai elimistön raudan tarve on lisääntynyt. Gastrointestinal side effects, mainly of low level, were reported in 27% of patients from the SI group, in accordance with data already reported in the literature [ 47]. It is not surprising that the totality of patients with side effects are 80 years old or older. In fact, 40% of elderly patients show gastrointestinal side effects [ 48, 62] and probably the high number of octogenarians with gastrointestinal side effects is only due to the low number of patients in our study. On the other hand, it is noteworthy that in patients taking Sucrosomial iron with food, gastrointestinal side effects are reduced to almost one-third (only 10%), a markedly lower percentage in comparison to previous studies. Sucrosomial® iron (SI) is a new oral iron formulation, in which ferric pyrophosphate is protected by a phospholipid bilayer membrane composed mainly by sunflower lecithin, enveloped in a sucrester matrix stabilized by other ingredients as tricalcium phosphate and starch, forming the “sucrosome,” absorbed as a vesicle-like structure, through intestinal M cells, through a paracellular or intracellular way [ 7]. Auerbach M, Ballard H, Glaspy J (2007) Clinical update: intravenous iron for anaemia. Lancet 369:1502–1504

Sideral voidaan ottaa milloin tahansa vuorokauden aikana, joka päivä, tauottaminen ei lisää sukrosomiaalisen raudan imeytymistä. Sideral voidaan ottaa ruokailun yhteydessä, muut ravintoaineet tai lääkeaineet eivät vaikuta imeytymiseen.Klip IT, Comin-Colet J, Voors AA et al (2013) Iron deficiency in chronic heart failure: an international pooled analysis. Am Heart J 165:575–582.e3. https://doi.org/10.1016/j.ahj.2013.01.017 Giordano G, Cutuli MA, Lucchesi A et al (2020) Iron support in erythropoietin treatment in myelodysplastic syndrome patients affected by low-risk refractory anaemia: real-life evidence from an Italian setting. Acta Haematol 143:155–162. https://doi.org/10.1159/000501329 Fievez V, Plapied L, Plaideau C et al (2010) In vitro identification of targeting ligands of human M cells by phage display. Int J Pharm 394:35–42. https://doi.org/10.1016/j.ijpharm.2010.04.023 A nu se lăsa la îndemâna și la vederea copiilor mici. A nu se depăși doza recomandată pentru consumul zilnic. A se consuma, de preferință, înainte de sfârșitul lunii menționate pe ambalaj. Produsul este un supliment alimentar și nu trebuie să înlocuiască o dietă variată și echilibrată și un mod de viață sănătos. The following assays were weekly performed: complete blood count, B 12, folates, haptoglobin, blood iron, ferritin, total iron binding capacity, liver enzymes, creatinine, blood urea nitrogen, C-reactive protein in the first 6 weeks of the study. All these tests were performed monthly during the entire follow-up period with fecal occult blood test.