Joined in 2023 
82 
63 About this deal
Dehydrocholesterol is the precursor of cholecalciferol. [2] Within the epidermal layer of skin, 7-dehydrocholesterol undergoes an electrocyclic reaction as a result of UVB light at wavelengths between 290 and 315nm, with peak synthesis occurring between 295 and 300nm. [38] This results in the opening of the vitamin precursor B-ring through a conrotatory pathway making previtamin D 3 (pre-cholecalciferol). [39] In a process which is independent of UV light, the pre-cholecalciferol then undergoes a [1,7] antarafacial sigmatropic rearrangement [40] and therein finally isomerizes to form vitamin D 3.
Some research suggests that obesity may be associated with low vitamin D levels. It’s also believed that vitamin D could influence body weight by regulating the growth of fat cells and altering the expression of certain genes and the levels of hormones that affect hunger, such as leptin [6] Karampela I, et al. Vitamin D and Obesity: Current Evidence and Controversies. Curr Obes Rep. 2021;10(2):162-180. . Kocher DK, Kaur G, Banga HS, Brar RS (2010). "Histopathological Changes in Vital Organs of House Rats Given Lethal Dose of Cholecalciferol (Vitamin D3)". Indian Journal of Animal Research. 2 (3): 193–6. ISSN 0367-6722. Use of cholecalciferol as a rodenticide in bait lowered the risk of secondary poisoning and minimized the toxicity of non-target species Very good! Vitamin D is essential to your overall health and making sure you get enough is paramount to your well-being. Before you get started, it is important to know that there are different types of vitamin D: vitamin D3 and vitamin D2.The number one way to maintain strong, healthy bones? Calcium! Your bones need calcium to maintain the health and mineral density of your precious skeleton, but as it turns out, getting enough vitamin D is essential to calcium absorption in your bones and body. During pregnancy, doses of vitamin D greater than the recommended dietary allowance should be used only when clearly needed. Discuss the risks and benefits with your doctor. While some studies have found that vitamin D 3 raises 25(OH)D blood levels faster and remains active in the body longer, [143] [144] others contend that vitamin D 2 sources are equally bioavailable and effective as D 3 for raising and sustaining 25(OH)D. [134] [145] [146] Food preparation [ edit ] The Swedish National Food Agency recommends a daily intake of 10 μg (400 IU) of vitamin D 3 for children and adults up to 75 years, and 20 μg (800 IU) for adults 75 and older. [127] Your skin is your largest organ and vitamin D is critical to its health. The active form of Vitamin D (calcitriol) helps with skin repair and growth. Vitamin D3 is the precursor to Calcitriol. As you get older your body loses the ability to produce D3 which leads to a weaker immune system and weaker skin. 3) Healthy Muscles
Shieh A, et al. Effects of High-Dose Vitamin D2 Versus D3 on Total and Free 25-Hydroxyvitamin D and Markers of Calcium Balance. J Clin Endocrinol Metab. 2016 ;101(8):3070-8. a b Ross AC, Taylor CL, Yaktine AL, Del Valle HB, etal. (Institute of Medicine (US); Committee to Review Dietary Reference Intakes for Vitamin D and Calcium) (2011). Dietary Reference Intakes for Calcium and Vitamin D (PDF). doi: 10.17226/13050. ISBN 978-0-309-16394-1. PMID 21796828. S2CID 58721779.Keflie TS, Nölle N, Lambert C, Nohr D, Biesalski HK (October 2015). "Vitamin D deficiencies among tuberculosis patients in Africa: A systematic review". Nutrition. 31 (10): 1204–12. doi: 10.1016/j.nut.2015.05.003. PMID 26333888. Cholecalciferol is also produced industrially for use in vitamin supplements from lichens, which is suitable for vegans. [42] [43] Stability [ edit ]
Before taking vitamin D, tell your doctor or pharmacist if you are allergic to it; or to other vitamin D products (such as calcitriol); or if you have any other allergies. This product may contain inactive ingredients (such as peanut/soy), which can cause allergic reactions or other problems. Talk to your pharmacist for more details. The mechanism of high dose cholecalciferol is that it can produce " hypercalcemia, which results in systemic calcification of soft tissue, leading to kidney failure, cardiac abnormalities, hypertension, CNS depression, and GI upset. Signs generally develop within 18-36 hr of ingestion and can include depression, loss of appetite, polyuria, and polydipsia." [15] High-dose cholecalciferol will tend to rapidly accumulate in adipose tissue yet release more slowly [45] which will tend to delay time of death for several days from the time that high-dose bait is introduced. [44] Vitamin D is essential for immune health and disease prevention. In fact, some research suggests vitamin D deficiency could worsen or increase the incidence of certain autoimmune conditions, such as rheumatoid arthritis [3] Ao T, et al. The Effects of Vitamin D on Immune System and Inflammatory Diseases. Biomolecules. 2021;11(11):1624. . “There is also evidence that maintaining vitamin D sufficiency reduces the long-term risk of developing certain types of cancer,” adds Dr. White. Keeping a healthy store of vitamin D gives added protection to such diseases as cancer, multiple sclerosis, and type 1 diabetes.
By itself cholecalciferol is inactive. It is converted to its active form by two hydroxylations: the first in the liver, by CYP2R1 or CYP27A1, to form 25-hydroxycholecalciferol ( calcifediol, 25-OH vitamin D 3). The second hydroxylation occurs mainly in the kidney through the action of CYP27B1 to convert 25-OH vitamin D 3 into 1,25-dihydroxycholecalciferol ( calcitriol, 1,25-(OH) 2vitamin D 3). All these metabolites are bound in blood to the vitamin D-binding protein. The action of calcitriol is mediated by the vitamin D receptor, a nuclear receptor which regulates the synthesis of hundreds of proteins and is present in virtually every cell in the body. [2] Biosynthesis [ edit ]
Great Deal 
New Comment