Acute Diarrhoea Relief Capsules 6 Capsule

Product Information

Nonsteroidal anti-inflammatory drugs (NSAIDs): NSAIDs such as ibuprofen and aspirin can irritate the lining of the stomach and intestines, leading to diarrhoea. Adults who have accidentally ingested less than 0.4mg/Kg and who have no new symptoms since the time of ingestion should be advised to seek medical attention if symptoms develop. This medicine only treats the symptoms of diarrhoea and should not be taken for long periods of time. In acute diarrhoea, if clinical improvement is not observed within 48 hours, the administration of Loperamide Hydrochloride should be discontinued and patients should be advised to consult their doctor.

Two capsules (4mg) initially followed by 1 capsule (2mg) after every loose stool (motion).The total daily dose should not exceed 6 capsules (12mg).

1. About loperamide

Acute and chronic studies on loperamide showed no specific toxicity. Results of in vivo and in vitro studies carried out indicated that loperamide is not genotoxic. In reproduction studies, very high doses (40 mg/kg/day – 20 times the maximum human use level (MHUL)), based on body surface area dose comparison (mg/m2), loperamide impaired fertility and fetal survival in association with maternal toxicity in rats. Lower doses (> 10mg/kg/day – 5 times MHUL) revealed no effects on maternal or fetal health and did not affect peri- and post-natal development. feeling dizzy – if loperamide makes you feel dizzy when you stand up, try getting up very slowly or stay sitting down until you feel better. If you begin to feel dizzy, lie down so that you do not faint, then sit until you feel better. Avoid driving, cycling, or using tools or machines if you feel dizzy.

Diarrhoea is a common symptom of a number of serious conditions in the stomach and bowel,if your diarrhoea lasts for a long time or keeps returning, talkto your doctor. Occasionally patients with a colostomy (stoma) need a higher dose. Only take a higher dose if your doctor tells you to. Children's doses Loperamide is also available combined with simeticone. Simeticone is used to treat farting (flatulence or wind). Taking these medicines together helps if you have diarrhoea with painful stomach cramps and bloating. Serious heart problems (symptoms of which include fast or irregular heartbeat) have been reported in patients who have taken too much loperamide, the active ingredient in this medicine.

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Loperamide is also used for recurring or longer lasting diarrhoea from bowel conditions such as Crohn's disease, ulcerative colitis and short bowel syndrome. Whenever an underlying aetiology can be determined, specific treatment should be given when appropriate. The priority in acute diarrhoea is the prevention or reversal of fluid and electrolyte depletion. This is particularly important in young children and in frail and elderly patients with acute diarrhoea. Use of this medicine does not preclude the administration of appropriate fluid and electrolyte replacement therapy. headaches – make sure you rest and drink plenty of fluids. Do not drink too much alcohol. Ask your pharmacist to recommend a painkiller. Talk to your doctor if the headaches last longer than a week or are severe. Your doctor will adjust your dose according to your symptoms and how well loperamide is working, up to a maximum of:

The illness usually lasts for a few days but can sometimes last longer, especially if left untreated.If you have an intolerance to some sugars, unless your doctortells you to (this medicine contains lactose) If you are constipated, or have any condition which may causeconstipation or where constipation should be avoided

Concomitant treatment with oral desmopressin resulted in a 3-fold increase of desmopressin plasma concentrations, presumably due to slower gastrointestinal motility. If you have dysentery (a disease caused by eating and drinkingcontaminated food and water) - you may have a fever andblood in your stools Cardiac events including QT interval and QRS complex prolongation and torsades de pointes have been reported in association with overdose. Some cases had a fatal outcome (see section 4.9). Overdose can unmask existing Brugada syndrome. Patients should not exceed the recommended dose and/or the recommended duration of treatment. Stomach pains, a swollen stomach, nausea, vomiting, constipation, flatulence (wind),indigestion and heartburnTravellers’ diarrhoea can often be prevented by practising good hygiene and food safety practices, such as washing hands frequently with soap and water, avoiding tap water, ice, and raw or undercooked foods, and choosing bottled water and food that has been cooked thoroughly. The most commonly reported (i.e. > 1% incidence) Adverse Drug Reactions (ADRs) in clinical trials with Loperamide Hydrochloride in acute diarrhoea were: Constipation (2.7%), Flatulence (1.7%), Headache (1.2%) and Nausea (1.1%). Morphine, on the other hand, is an opioid analgesic that can reduce the contractions of the intestinal muscles, which can help to reduce the speed of stool passage through the intestines and alleviate the symptoms of diarrhoea. Only take this medicine to treat acute episodes of diarrhoea associated with Irritable Bowel Syndrome (IBS) if your doctor has previously diagnosed IBS.