Pet Wellbeing Milk Thistle for Cats - Supports Liver Health, Protects Liver - Glycerin-Based Natural Herbal Supplement - 2 oz (59 ml)

Product Information

The ingredients in Denamarin can help to protect liver cells from toxins and inflammatory damage through the actions of silybin, as well as improve liver function through SAMe’s involvement with major metabolic processes of the liver. Due to the antioxidant properties, Milk Thistle may help reduce or slow down the growth of specific cancer cells. Among the few papers we found with our search criteria, there are also a couple of case reports, in which a combination of active principles was used, including silybin and S-adenosylmethionine: one regarding a cat and one a dog. The former was a young adult female cat presented with acute neurological signs, pyrexia, and increased ALT/GPT, AST/GOT, and bilirubin, diagnosed after a complete diagnostic work up with hepatitis caused by Yersinia pseudotuberculosis. Successful treatment included antimicrobials, combination of S-adenosylmethionine and silybin, and fluid therapy [ 23]. The latter was about an adult female Pug dog diagnosed with toxic hepatopathy, caused by microcystins present in a dietary supplement that was given to the dog. After a very articulated therapeutic protocol including S-adenosylmethionine and silybin, ursodeoxycholic acid, N-acetylcysteine, antimicrobials, dolasetron, metoclopramide, vitamins K and B, and fluids, the cat fully recovered from hepatopathy [ 25]. Throughout these appetite struggles, Mimi was also dealing with another symptom, constipation. It is likely that a cat with gastrointestinal lymphoma to have some issues with doing its business. In Mimi’s case, he was having a hard time with his bowel movements as the tumor was likely taking up space in his intestines, making it uncomfortable and difficult. After a couple of days, we received a happy update from Lesley that Mimi was feeling much better after being able to do his business.

To assess the possible efficacy of nutraceuticals on liver diseases, studies on cell cultures have also been carried out on single molecules/complexes or on their combination, with not always concordant results. A recent study reports the effects of a pretreatment with the combination of S-adenosylmethionine and silybin on primary canine hepatocytes exposed to the proinflammatory cytokine IL-1 β, and these molecules are hypothesized as a possible support to the liver function. Indeed, the presence of this combination was associated with reduced levels of PGE 2, IL-8, and macrophage chemotactic protein-1 (proinflammatory molecules induced by IL-1 β administration) as well as to higher glutathione (GSH) levels (reduction of oxidative stress) [ 20]. Similarly, a previous study by the same authors reported the efficacy of silybin and of a silybin-phosphatidylcholine complex in canine primary hepatocyte cultures exposed to IL-1 β, as demonstrated by a significant reduction of proinflammatory markers (PGE 2, IL-8, and monocyte chemotactic protein-1) and by a decreased NF- κB nuclear translocation, for the silybin-phosphatidylcholine complex [ 22]. On the other hand, in a study on cultured canine hepatocytes, the exposition to silibinin and simultaneously to α-amanitin, a known liver toxin from amanitin containing mushrooms (e.g. Amanita phalloides), did not show protective effects on those cells, which are measured by hepatocytes viability and lactate dehydrogenase activity measurement [ 21]. 3.2. S-Adenosylmethionine (SAMe) To be taken twice daily. Determine your pet’s weight and then use the easy chart below to determine the correct dose. This is the minimum dosage.

Milk Thistle is a safe herb that is well tolerated by your pet. It is herb that is recommend and used by holistic practitioners Milk thistle, also known as Silybum Marianum is an herb that has been used for thousands of years by humans for its powerful medicinal properties. The active ingredient is Silymarin which contains flavonoids that have many beneficial properties including: Full-Spectrum Extract: The full biochemical spectrum of the herbs is preserved to ensure the potency of the extract. All raw materials are tested for identification and purity.

Denamarin tablets are typically dosed once a day per the manufacturer’s advice. However, there are many reports that the most effective dosages for SAMe and silybin for certain conditions may need to be higher than the Denamarin label states. For about three weeks now this has yielded about 95% success on the first try. A few times he’s super sneaky and spit it out…lol.

Singh, S., Shukla, S.K., Bhatt, P and Singh, A. K. (2019). Clinico therapeutic studies on ascites in canines. International Journal of Current Microbiology and Applied Sciences, 8(9): 1120-1137. Retrieved from https://doi.org/10.20546/ijcmas.2019.809.129 Milk Thistle for dogs and cats is a key natural ingredient to support elderly pets due to its multi-health benefits. FDA Registered Facility: Our manufacturing facility is FDA registered. Strict quality control procedures are meticulously monitored. Milk Thistle’s beneficial effects are largely down to the active compound found in the seeds and fruit called silymarin. There are however other compounds present in the fruit that also have a potential role to play in supporting the liver, and wider body. Healthy oils such as linoleic acid, flavenoids, and vitamin E are all known for their antioxidant (to neutralise free radicals) and immune supportive action and all are present in the Milk Thistle fruit. If you’re using the regular enteric-coated tablets, these should not be split or crushed as it will affect the absorption as well as the dosage, so I wouldn’t do that without speaking with your vet first.

If you use the liquid tincture, you can easily dose it using the dropper it comes with. The dropped is usually marked so you know exactly how much of the substance you administer to your cat. The dosage should be calculated according to the body weight: 1 drop per 2 pounds. It is recommended that you divide the dose for 2 or more administrations a day. This supplement by NHV Natural Pet Products uses 100% natural milk thistle to support dogs through liver and kidney conditions in addition to conventional treatment by their veterinarian. Liver Support BenefitsThis article takes an in-depth look at milk thistle and its role in effectively treating your pets. What Is Milk Thistle?