MAGNE B6 MAX - 50 Capsules - is a Dietary Supplement containing in its Composition Magnesium and Vitamin B6, for People Suffering Weakness, Fatigue, Twitching eyelids and Muscle spasms

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This is partly because this vitamin is necessary for creating neurotransmitters that regulate emotions, including serotonin, dopamine and gamma-aminobutyric acid (GABA) ( 3, 4, 5). Mocellin S, Briarava M, Pilati P (March 2017). "Vitamin B6 and Cancer Risk: A Field Synopsis and Meta-Analysis". J Natl Cancer Inst. 109 (3): djw230. doi: 10.1093/jnci/djw230. PMID 28376200. An overview of the history was published in 2012. [48] In 1934, the Hungarian physician Paul György discovered a substance that was able to cure a skin disease in rats (dermatitis acrodynia). He named this substance vitamin B 6, as numbering of the B vitamins was chronological, and pantothenic acid had been assigned vitamin B 5 in 1931. [49] [50] In 1938, Richard Kuhn was awarded the Nobel Prize in Chemistry for his work on carotenoids and vitamins, specifically B 2 and B 6. [51] Also in 1938, Samuel Lepkovsky isolated vitamin B 6 from rice bran. [48] A year later, Stanton A. Harris and Karl August Folkers determined the structure of pyridoxine and reported success in chemical synthesis, [52] and then in 1942 Esmond Emerson Snell developed a microbiological growth assay that led to the characterization of pyridoxamine, the aminated product of pyridoxine, and pyridoxal, the formyl derivative of pyridoxine. [48] Further studies showed that pyridoxal, pyridoxamine, and pyridoxine have largely equal activity in animals and owe their vitamin activity to the ability of the organism to convert them into the enzymatically active form pyridoxal-5-phosphate. [48] a b Schorgg P, Bärnighausen T, Rohrmann S, Cassidy A, Karavasiloglou N, Kühn T (May 2021). "Vitamin B6 Status among Vegetarians: Findings from a Population-Based Survey". Nutrients. 13 (5): 1627. doi: 10.3390/nu13051627. PMC 8150266. PMID 34066199. Mayengbam S, Chleilat F, Reimer RA (November 2020). "Dietary Vitamin B6 Deficiency Impairs Gut Microbiota and Host and Microbial Metabolites in Rats". Biomedicines. 8 (11): 469. doi: 10.3390/biomedicines8110469. PMC 7693528. PMID 33147768.

Researchers suspect that B6 helps with emotional symptoms related to PMS due to its role in creating neurotransmitters that regulate mood. The contradictory results of these studies may be due to the difference in vitamin B6 dose and study length. Kobayashi D (2019). "[Food Poisoning by Ginkgo Seeds through Vitamin B6 Depletion]". Yakugaku Zasshi (in Japanese). 139 (1): 1–6. doi: 10.1248/yakushi.18-00136. PMID 30606915. In 2010, the European Food Safety Authority (EFSA) published a review of proposed health claims for vitamin B 6, disallowing claims for bone, teeth, hair skin and nails, and allowing claims that the vitamin provided for normal homocysteine metabolism, normal energy-yielding metabolism, normal psychological function, reduced tiredness and fatigue, and provided for normal cysteine synthesis. [36]

The reason why B6 may help prevent cancer is unclear, but researchers suspect that it’s related to its ability to fight inflammation that may contribute to cancer and other chronic conditions ( 34, 35). Adverse effects have been documented from vitamin B 6 dietary supplements, but never from food sources. Even though it is a water-soluble vitamin and is excreted in the urine, doses of pyridoxine in excess of the dietary upper limit (UL) over long periods cause painful and ultimately irreversible neurological problems. [4] The primary symptoms are pain and numbness of the extremities. In severe cases, motor neuropathy may occur with "slowing of motor conduction velocities, prolonged F wave latencies, and prolonged sensory latencies in both lower extremities", causing difficulty in walking. Sensory neuropathy typically develops at doses of pyridoxine in excess of 1,000mg per day, but adverse effects can occur with much less, so intakes over 200mg/day are not considered safe. [4] Trials with amounts equal to or less than 200mg/day established that as a " No-observed-adverse-effect level", meaning the highest amount at which no adverse effects were observed. This was divided by two to allow for people who might be extra sensitive to the vitamin, referred to as an "uncertainty factor", resulting in the aforementioned adult UL of 100mg/day. [4] Labeling [ edit ] Due to its role in hemoglobin production, vitamin B6 may be helpful in preventing and treating anemia caused by deficiency ( 19). Vitamin B6 may play a role in improving brain function and preventing Alzheimer’s disease, but the research is conflicting.

While it appears that high doses of vitamin B6 supplements may provide anti-inflammatory benefits for people with rheumatoid arthritis over time, more research is needed.a b c d e f g h Da Silva VR, Gregory III JF (2020). "Vitamin B6". In BP Marriott, DF Birt, VA Stallings, AA Yates (eds.). Present Knowledge in Nutrition, Eleventh Edition. London, United Kingdom: Academic Press (Elsevier). pp.225–38. ISBN 978-0-323-66162-1. Ristilä M, Strid H, Eriksson LA, Strid A, Sävenstrand H (March 2011). "The role of the pyridoxine (vitamin B6) biosynthesis enzyme PDX1 in ultraviolet-B radiation responses in plants". Plant Physiol Biochem. 49 (3): 284–92. doi: 10.1016/j.plaphy.2011.01.003. PMID 21288732. Vitamin B6 may also play a role in decreasing high blood levels of the amino acid homocysteine, which have been linked to depression and other psychiatric issues ( 6, 7).